| Wright State Research Institute | Ceased exchange 2015 |
Community Health Information Collaborative
| Ceased operations 2015
|
Idaho Health Data Exchange
| 2016 |
Redwood MedNet, Inc.
| Ceased operations 2017
|
Douglas County Individual Practice Association
| Ceased operations 2017
|
Texas Health Services Authority
| 2017 |
Medical Information Network- North Sound
| Ceased operations 2018 |
| SacValley MedShare | Now exchanging via another Participant (CAHIE) 2021
|
| West Virginia HIE | Now exchanging via another Participant (CRISP) 2021
|
Great Lakes Health Connect
| Now exchanging via another Participant (MiHIN) 2021
|
Michiana HIN
| Now exchanging via another Participant (IHIN) 2021
|
InterCommunity Health Network
| Ceased operations 2021
|
HealthIX
| Terminated by Coordinating Committee 2021 |
HealtheConnections
| Terminated by Coordinating Committee 2021
|
| Renal Services Exchange | Ceased operations 2021 |
| National Renal Association (NRAA) | Changed reporting model to CMS in September 2021 |
| healtheConnect Alaska, formerly Alaska eHealth Network | Now exchanging via another Participant (CRISP) 2021 |
| Southeast Michigan Health Information Exchange | Now exchanging via another Participant (MiHIN) |
| South Country Health Alliance | Ceased operations 2022 |
| Southeast Coalition on Health (SECOH) | Ceased operations 2022 |
| Florida Health Information Exchange (FLHIE) | December 2022 |
| Strategic Health Intelligence - Pensacola HIE | January 2023 |
| Health Collaborative (Healthbridge) | January 2023 |
| Tampa Bay Regional Health Information Exchange Organization (TBRHIO) | February 2023 |
| Coordinated Care Health Network (CCHN) | Ceased operations 2023 |
| Coastal Connect Health Information Exchange (CCHIE) | July 2023 |
| South Carolina Health Information Exchange (SCHIEx) | July 2024 Note: Shared Gateways and Nodes are not added to this listing. |
| Orange County Partnership Regional Health Information Organization (OCPRHIO) formerly One California Partnership Regional Health Information Organization | Ceased operations 2024 |
| Delaware Health Information Network (DHIN) | November 2024 |
| Rhode Island Quality Institute (RIQI) | February 2025 |
| San Mateo County Connected Care (Node, CAHIE) | July 2025 |
